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As smaller adipocytes are highly insulin sensitive 36 , P5 by shifting the balance towards hyperplasia might restore insulin signalling and increase lipid storage capacity in eWAT resulting in improved glucose homeostasis and redistribution of lipids from ectopic deposits in liver to adipocytes

Sorensen et al., 2004)

Target identification is the most valuable line of work available, because it addresses the actual gap

risks include gastrointestinal effects, overlapping hepatic metabolism, injection site reactions, and hypoglycaemia, with urgent review required for severe abdominal pain, jaundice, or signs of dehydration