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While there's no upper limit to how much vitamin B12 you can take, there are general dosage recommendations

The reasons are multifactorial: chronic inflammation damages blood vessel walls, corticosteroid use raises cholesterol and blood pressure, lupus-specific antibodies (particularly antiphospholipid antibodies) increase clotting risk, and the metabolic disruption caused by both the disease and its treatments creates a perfect storm for atherosclerosis

Perhaps you are concerned about memory loss or dementia in a loved one

B12 is necessary for the production of serotonin, a chemical responsible for regulating mood