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Conjugated equine estrogens are a mixture of sodium estrone sulfate and sodium equilin sulfate among other estrogenic substances derived from pregnant mare urine or synthetically derived.15 Conjugated equine estrogens 0.625mg orally is thought to approximately correspond with the estrogenic effect of 1-2mg estradiol orally.10 Some studies suggest that oral CEE may be more prothrombotic and have a greater impact on blood pressure as compared to other estrogens such as estradiol

Hypoglycaemia: Whilst these agents are not expected to cause low blood sugar on their own, people with diabetes who are also taking insulin or sulfonylureas may be at increased risk of hypoglycaemia

It does not affect blood glucose

Once the sgRNA has bound to this region, the dCas9 fused to the appropriate transcriptional activators will be recruited