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That last area is getting the most attention now

In 2003, a Cochrane review of three RCTs on cognitive function in patients with AD or other forms of cognitive impairment also found no evidence of benefits of B12 on cognitive function compared with placebo

Duration by dose The number of weeks your vial lasts depends entirely on your weekly dose: If you follow the standard titration schedule starting at 2.5 mg and increasing every four weeks, a single 60 mg vial provides: Weeks 1-4 at 2.5 mg = 10 mg used Weeks 5-8 at 5 mg = 20 mg used Weeks 9-12 at 7.5 mg = 30 mg used Total: 60 mg consumed over 12 weeks That is three full months of a complete titration protocol from one vial

No pharmaceutical company, no academic medical center, and no government agency has found the existing preclinical data compelling enough to fund a rigorous human trial in over 30 years