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Participants were assessed at baseline, 3 months, and 12 months for clinical parameters, dietary intake, and eating behaviors using validated tools (Food Frequency Questionnaire and the Japanese version of the Dutch Eating Behavior Questionnaire [DEBQ-J])

Liver/Kidney Conditions: Individuals with liver or kidney disorders should consult a healthcare professional before beginning this treatment

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Compared with disulfide-based systems, which are widely used due to their simplicity and predictable cleavage by intracellular GSH, diselenide linkages offer greater redox sensitivity and can respond to both GSH and ROS