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IGF-1 LR3 has an arginine instead of a glutamic acid at the third position in its amino acid sequence and an additional 13 amino acids at its N-terminus

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It serves as the primary intracellular reducing agent for reactive oxygen species (ROS), a cofactor for glutathione peroxidase (GPx), and a central mediator of hepatic detoxification via glutathione Stransferase (GST) and the glutamyl cycle

doi: 10.1371/journal.pone.0233208 106 MakhezerNBen KhemisMLiuDKhichaneYMarzaioliVTliliAet al