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Side Effects Common Side Effects: These side effects are typically mild and tend to resolve as the body adjusts to the medication: Gastrointestinal symptoms: Nausea (most common, especially during dose escalation) Vomiting Diarrhea Constipation Abdominal pain or discomfort Decreased appetite: Semaglutide can reduce appetite, which may lead to weight loss, a known effect of the drug

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