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In CRS mice, THC administration reversed anxiety- and depressive-like behaviors (open field, tail suspension, and forced swim tests), normalized prefrontal cortex (HSP90, KRT6A, P4HB, C1QA, APOM, CDH13) and hippocampal (HSP90, P4HB, CDH13) protein expression in mice, and restored serum levels of P4HB, C1QA, and CDH13 in both humans and mice, while additionally modulating LTF, TNF-, IL-1, cAMP, and DA in mice serum
A small but growing body of evidence has explored this question: Castaeda et al., 2025 ( Lancet Obstetrics, Gynaecology & Womens Health ) Postmenopausal women treated with tirzepatide who were also using menopausal hormone therapy lost approximately 35% more weight than non-users
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