Sleigh JN, Rossor AM, Fellows AD et al (2019) Axonal transport and neurological disease
Cancer Cell 38(2):167197 Spranger S et al (2017) Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy
Key research themes involving glutathione include: Scavenging of free radicals (e.g., peroxides, nitrogen dioxide, hypochlorous acid) Support of other antioxidant systems (e.g., vitamin C and vitamin E recycling) Detoxification via glutathione S-transferases and related enzymes Regulation of protein folding, disulfide-bond formation, and thiol redox status Modulation of inflammatory mediators, nitric oxide pathways, and cellular metabolism Because endogenous glutathione synthesis capacity appears to decrease with age in many models, glutathione is frequently used as both an experimental variable and a biomarker in studies of aging, disease susceptibility, and redox imbalance
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