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Overproduction of ROS and abnormal infiltration of immune cells may be involved in lupus nephritis (LN) due to ferroptosis, as suggested by a bioinformatics study that identified eight ferroptosis-related genes (including KRAS , Mapk14 , PIK3CA , EGFR, SRC , mapk3 , ATM and VEG ) that might be promising biomarkers of ferroptosis in LN [163]