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49 In 2014, the PARADIGM-HF randomised trial demonstrated that a combination of sacubitril and valsartan was superior to enalapril in reducing the risks of death and of hospitalisation for HF, with a number needed to treat (NNT)of 14 for the primary outcome of cardiovascular (CV) mortality or HF hospitalisation

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A standard household freezer at -18C to -20C is acceptable for lyophilized BPC-157 long-term storage