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People with a personal or family history of a medical condition called multiple endocrine neoplasia type 2 (MEN2) or medullary thyroid cancer should not take Wegovy and other weight loss drugs from the same drug class

Additionally, in high-fat-diet-induced obese mice, miR-194 overexpression through transcription factor 7-like 2(Tcf7l2) and forkhead box a1(Foxa1) inhibits proglucagon ( Gcg) and Pcsk1 gene transcription, ultimately suppressing GLP-1 synthesis in L-cells [33]

tirzepatide adds GIP (dual agonist) and retatrutide adds glucagon (triple agonist), with generally larger weight effects in trials but different tolerability profiles

Wu et al., 2022