glp 1 amylin Forget GLP-1: Wants to Be the Next Big Thing PEGylated prodrugs of antidiabetic peptides

and Metabolism 95 (1), 215221

Daily dose: 1mL (1mg semaglutide)

Abbreviations KOA: Knee osteoarthritis LPS: Lipopolysaccharide FLS: Fibroblast-like synoviocytes AMPK: AMP-activated protein kinase CPT1: Carnitine palmitoyltransferase 1 Cyc: Cytochrome c ACLT: Anterior cruciate ligament transection NSAIDs: Non-steroidal anti-inflammatory drugs CoA: Coenzyme A SOD: Superoxide dismutase MDA: Malonaldehyde ATP: Adenosine-triphosphate ROS: Reactive oxygen species CCK-8: Cell counting kit-8 DMEM: Dulbeccos modified Eagles medium IL-1: Interleukin-1 siRNA: Small interfering RNA References Sharma L

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