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Adverse effects and challenges Short-term adverse effects, such as fatigue, irritability, headache, nausea, dehydration, hypoglycemia, diarrhea, metabolic acidosis, and refusal to eat, are commonly seen during the first few weeks of the KD as responses to diet-induced metabolic shift and are usually predictable and preventable

This can result in an increased susceptibility to metabolic stress, a factor that greatly accelerates the aging process

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