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Methods Samples In this study, 3D InSight TM Human Cardiac Microtissues (InSphero, for beta-testers) were used, containing a co-culture of approximately 4000 iPSC-derived human cardiomyocytes from a female Caucasian donor with no known disease phenotype and 1000 cardiac fibroblasts from an 18 year old Caucasian male

42 , e168e185 (2022)

In cardiac MTs, the downregulated genes in miRNA biogenesis could explain the extremely high amount of downregulated DE miRNA and indicate extreme deregulation of gene silencing by miRNAs