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Excessive iron accumulation in the brains of PD patients, causing oxidative stress, leads to the degradation of nigral dopaminergic neurons, a characteristic feature of the disease

Since changes in are suppressed at the level of Hcy, examining the methionine cycle in greater detail holds the key to understanding the discrepancy between the predictions of the remethylation block hypothesis and the Reed-Nijhout model

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J Pharmacol Sci 2018;136, 42-45, doi:10.1016/j.jphs.2017.12.008