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Inherited haemolytic states : Glucose 6-phosphate dehydrogenase deficiency

Stressors, hormones, growth, and a variety of additional metabolic pathways can all arouse ROS formation, which can then trigger other pathways or serve as direct defense compounds in the plant body [43]

ROS and RNS production are facilitated by pattern recognition receptors [C-reactive protein (CRP), toll-like receptors] capable of recognizing pathogen (bacterial/viral)-associated molecular patterns and/or damage-associated molecular patterns in apoptotic or damaged cells (92100) (Figure 6)

It may be possible to use a splint for six weeks (instead of casting) and then start physical therapy