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Weighing these trade-offs is an important part of any decision to use medication

It originates from the preproglucagon precursor, which undergoes enzymatic processing within intestinal L-cells, ultimately giving rise to GLP-1(1-37) and GLP-1(7-36) amide or GLP-1(7-37) peptide variants.30,31 GLP-1 is an incretin hormone that plays a pivotal role in the meticulous control of human blood glucose levels.32,33 Nevertheless, its duration of action is rather ephemeral, lasting a mere 12 min within the circulatory system under typical physiological conditions.34,35 Subsequently, GLP-1 undergoes enzymatic degradation facilitated by dipeptidyl peptidase IV (DPP-4), leading to the loss of its biological efficacy.36 GLP-1 GLP-1

Clinical evidence indicates that treatment with GLP-1RAs for durations of 1 to 3 years or longer may be associated with an elevated risk of thyroid carcinoma, particularly medullary thyroid carcinoma [4]

2 Ozempic y Wegovy son lo mismo