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Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)

That said, there are still some risks associated with supplementing vitamin B12 if you arent deficient: A 2015 study found that excess vitamin B12 is associated with acne and rosacea

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Methylcobalamin is the most expensive form of B12 however is favoured by Dr Knight due to its effectiveness with patients remotely and in clinic