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Virus protein ligands, like trimeric spike glycoprotein interact with cellular receptors, such as ACE2, and host proteases, like transmembrane protease serine 2 (TMPRSS2), participate in virus entry by proteolytically activating virus ligands (Sallenave and Guillot, 2020

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Although researchers believe that the cytokines are critical for the crosstalk between ferroptosis cells and immune cells, the mechanism remains unclear