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Based on the available data from AWARD-11, 66.4% of study volunteers given 4.5mg/weekly of dulaglutide had at least one side effect

Liraglutide treatment ameliorates IL-1-induced ROS production in cardiomyocytes, protects against IL-1-induced loss of mitochondrial membrane potential and decreased ATP generation, and counteracts IL-1-induced alterations in AMPK and acetyl-CoA carboxylase phosphorylation as well as the reduction of peroxisome proliferator-activated receptor coactivator-1 (PGC-1), which is a key regulator whose downregulation leads to cardiac mitochondrial dysfunction (168)