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TLDR: "Discontinuation of GLP-1RA treatment leads to weight regain, regardless of lifestyle interventions, and should therefore be considered a chronic therapy to prevent weight regain and associated undesirable outcomes related to obesity." Key findings: After stopping liraglutide, patients regained ~2.2 kg After stopping semaglutide/tirzepatide, patients regained ~9.7 kg Weight regain was proportional to initial weight loss Lifestyle changes alone DID NOT prevent regain Implication: GLP-1 receptor agonists are not a short-term solution

Are there strategies to minimize side effects while maintaining the approved dosing schedule, such as dietary modifications or anti-nausea medications

Proper Preparation: Cooking techniques matter for example, using minimal processed ingredients, adding fermented sides, or combining foods to maximize nutrient absorption

Beyond the primary endpoint, the trial revealed a 22 percent reduction in a composite kidney endpoint, suggesting renal protective effects