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This is due to a change in carbohydrate metabolism, specifically an increased production of the pro-inflammatory acetate and a decreased production of butyrate, which strengthens the intestinal barrier and has anti-inflammatory effects (162)

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Conversely, the role of PKC in internalization was ruled out using activators of this kinase in the locus coeruleus neurons expressing the FLAG-tagged MOR (Arttamangkul et al., 2014)

If you have symptoms suggestive of deficiency such as persistent fatigue, neurological symptoms, or unexplained anaemia, consult your GP before self-supplementing