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The catalytic activity of the molecule appears to be involved in at least some of these actions, and several endogenous substrates have been identified, although a role for protease-independent functions related to metabolic homeostasis has also been suggested

Central Alpha-2 Agonists Examples: Clonidine Methyldopa (safe in pregnancy) Side effects: Sedation Rebound hypertension if stopped abruptly 8

Glucagon-like peptide 1 agonists (GLP-1) and Gastric inhibitory polypeptide (GIP) have emerged as valuable therapeutic agents for managing obesity and type 2 diabetes

What the Third Receptor Adds Glucagon is the counter-regulatory hormone: it tells the liver to release stored glucose