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A phase I study of SPI-077 (stealth liposomal cisplatin) concurrent with radiation therapy for locally advanced head and neck cancer

Patients with AS can often develop kidney failure (KF) early in life

Clinical trial data suggests comparable GI side effect profiles, though some patients who cannot tolerate one medication do better on the other due to individual receptor sensitivity differences

315,316 For example, bile duct ligation induces hepatic inflammation and sickness behaviors accompanying with the increased levels of hepatic IL-6 and circulatory IL-6