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Contact your GP if natural approaches have not improved metabolic health after 3-6 months, if you have type 2 diabetes or pre-diabetes (HbA1c 42-47 mmol/mol), or if you struggle with obesity-related complications

A typical semaglutide titration: Weeks 1-4: 0.25mg once weekly Weeks 5-8: 0.5mg once weekly Weeks 9-12: 1.0mg once weekly Weeks 13-16: 1.7mg once weekly Week 17 onward: 2.4mg once weekly (maximum maintenance dose) A typical tirzepatide titration: Weeks 1-4: 2.5mg once weekly Weeks 5-8: 5.0mg once weekly Weeks 9-12: 7.5mg once weekly Weeks 13-16: 10mg once weekly Week 17 onward: 12.5-15mg once weekly (if needed) Some researchers find their optimal dose well below the maximum

For example, if you paused at week 4 with 10 units per week, and are ready to resume at week 6, move up to 12 units per week when you return

But over the next few years, she says, at least there will be more tools to better target treatment