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doi: 10.1164/rccm.201910-1911tr 10

If the hyperglycemic status is persistent, enhanced SGLT1/2 expression leads to paradoxically higher rates of glucose reabsorption [7]

So it is my contention that there must be some close relationship between taking Gymnema over a long period of time and some impact on the production or some aspect of GLP-1 biology

This enhancement is demonstrable through an increase in mitochondrial DNA content, the upregulation of genes integral to mitochondrial biogenesis, and the increased expression of proteins pivotal in oxidative phosphorylation