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Material can appear clean by conventional chromatography while still containing sequence variants, deamidation, oxidation, acylation variants or other subtle modifications that could affect potency, stability and potentially immunogenicity

Conclusion In summary, our findings suggested that when used at the optimal doses, acarbose has a comparable glucose-lowering efficacy to that of DPP-4is, but it is superior in the weight loss effect

Blood pressure improvements appear with both medications, typically in the range of 5 to 10 mmHg systolic reduction

Low homocysteine B12 levels are common when digestion is poor or intake is too low