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The methionine remethylation step can be facilitated by several intermediates such as the well known reaction mediated by folic acid and its active metabolites to form 5-methyltetrahydrofolate (5-MTHF) creating tetrahydrofolate (THF) which will then regenerate to 5-MTHF through the action of methylenetetrahydrofolate reductase (MTHFR)

That being said, its worth noting that GLP-1s may actually be beneficial for IBD patients who are stable, since weight loss can lessen inflammation, which can worsen symptoms of these conditions, Holly Lofton, MD, clinical associate professor of medicine and director of the Weight Management Program at NYU Langone Health, tells SELF

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