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Symptoms may include: Itching, soreness or swelling around the anus Bright red blood after opening the bowels Pain or discomfort when sitting or passing stools A feeling of incomplete emptying Mucus on toilet paper or underwear For some people, symptoms settle within days

The underlying mechanisms have not been fully delineated but are likely to involve modulation of the brain dopamine reward system via GLP-1 receptors, which are present both in the ventral tegmental areas (VTA), where dopamine neurons are located, and in the nucleus accumbens (NAc), which is the main projection of VTA dopamine neurons 14

Amount Per Serving: Folate 150 mcg 38%

For decades, patients were told that inability to lose the "spare tire" was simply a lack of discipline