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Metabolic disorders, particularly type 2 diabetes mellitus (T2DM) and obesity, contribute significantly to this burden, affecting over 460 million people worldwide with diabetes and creating a substantial interplay between metabolic and cardiovascular pathophysiology [1,2]

Surgery may be the better fit if your goal is to reduce or eliminate long-term prescriptions not just for weight loss, but for related conditions like diabetes or hypertension

As a synthetic analog of its endogenous exendin-4, compared with exendin-4, LIXI deleted one proline and added six lysine residues, which increased its binding affinity with the GLP-1R by four times and increased its circulating half-life (58, 59)

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