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hypothesized that in obesity-related insulin resistance (IR), skeletal muscle may decrease FAO because of decreased CACT activity 58

Currently, this endosomal escape process remains highly inefficient, representing a critical barrier to achieving potent and sustained target degradation (Table 2) [222, 223]

Visceral adiposity, more closely reflected by waist circumference, is particularly implicated in cardiovascular risk due to its pro-inflammatory and metabolic effects

The Once for Scotland advice is designed to inform the process of making injectable weight management drugs available and to prevent variation between Health Boards across Scotland