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A cross-sectional study in Sweden showed that a lack of social support was one of the biggest obstacles to long-term weight loss

Vilceanu, D., Honore, P., Hogan, Q

Similar to the transcriptomic changes observed in the hypothalamus, we found that the conjugate prompted transcriptional patterns enriched for functional terms associated with synaptic transmission, including postsynaptic specialization and neuron-to-neuron synapse in the brainstem (Extended Data Fig