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Your blood pressure would increase. The reasoning is the same for obesity, Saad asserted, since, like diabetes mellitus and hypertension, it is a chronic disease, and must be treated accordingly. It is clear, he said, that treatment must be individualized, and that some patients can gradually reduce medication, but this does not happen with the majority, and early cessation of treatment can lead to weight regain. Mir Ali, MD, a board-certified general surgeon, bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, CA, who was not involved in the meta-analysis, suggested several ways to help avoid adverse gastrointestinal effects, the first of which is limiting dose sizes as much as possible