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After the pharmaceutical development program concluded in 2007, the accumulated safety dataset was submitted in support of a US FDA Generally Recognized as Safe (GRAS) determination for AOD9604 as a dietary ingredient

Specifically, SIRT1 deacetylates autophagy-related proteins, such as Atg5, Atg7, and LC3, thereby facilitating autophagosome formation and enhancing lipophagy the selective degradation of lipid droplets that reduces triglyceride accumulation (Lee et al