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Butyric acid activates the Nrf2 pathway to increase the activity of antioxidant enzymes such as superoxide dismutase (SOD2), catalase (CAT), and glutathione peroxidase (GPx), reduce the oxidative damage caused by ROS, and maintain the integrity of the intestinal barrier 154

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It acts on receptors in the brain, particularly in the hypothalamus, to reduce appetite and increase feelings of fullness

Your provider will need to document that you still meet all of the requirements above and also the new requirements for continuing therapy: You have also lost at least 5% of your baseline body weight since you started using Zepbound