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Signals from the gut influence appetite, satiety, and energy balance through: The vagus nerve Hormonal signaling Microbial metabolites Key metabolic hormones produced or influenced by the gut include: GLP-1 (glucagon-like peptide-1) enhances insulin secretion and promotes satiety Peptide YY (PYY) signals fullness Ghrelin stimulates hunger When gut health is disrupted, these signals can become dysregulated, potentially contributing to overeating or impaired metabolic control
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Akt and eNOS are proteins that work farther down the same signaling route
Thats not a dismissal of the compound its where the science currently sits
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