Activation of PLC- in these cells induces the phosphorylation of PKC-, leading to the translocation of NF-B and Jun N-terminal protein kinase (JNK) inside the nucleus, resulting in increased production of inflammatory cytokines ( Figure 4 )
3.4 Poor outcomes and immunosuppressive drugs administered during follow-up in patients with AAV During follow-up after diagnosis, among the 71 patients, 6 (8.5%) died, and 17, four, and one had ever experienced and suffered from ESKD, CVA, and ACS, respectively
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