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Researchers randomly assigned 751 adults with obesity (but without type 2 diabetes) to receive either tirzepatide or semaglutide once a week by injection for 72 weeks that's about 17 months

But the composition of that weight loss is not ideal for someone who has spent years building muscle

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MOTS-c-overexpressing NIT-1 cells showed an increased mitochondrial number and restored curved mitochondrial cristae, contributing to enhanced mitochondrial function 56 , as opposed to the previously observed bulged mitochondria (Fig