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Do not open the refrigerator door to check on the medication, as this lets warm air in and reduces the cold reserve

A study of orforglipron (LY3502970) in adults with obesity or overweight (ATTAIN-1)

Additionally, GIP-mediated cAMP elevation activates exchange protein directly activated by cAMP 2 (Epac2), which stimulates ryanodine receptors (RYRs) on the endoplasmic reticulum to release stored calcium, further increasing cytosolic Ca concentration