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it can lead to severe health conditions such as type 2 diabetes, heart disease, high blood pressure, and certain cancers
Use with Medications Known to Cause Hypoglycemia Sitagliptin As is typical with other antihyperglycemic agents used in combination with a sulfonylurea, when sitagliptin was used in combination with metformin and a sulfonylurea, a medication known to cause hypoglycemia, the incidence of hypoglycemia was increased over that of placebo in combination with metformin and a sulfonylurea [see Adverse Reactions]
It refers to gradually increasing the dose of GLP-1 medications to improve effectiveness while minimizing side effects
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