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665 HIF-1 enhances the expression of the GLUTs GLUT1, LDH, PKM2, and PDH kinase (PDK1)

After treating human hepatocytes with prednisolone, the active metabolite of prednisone, and CsA at concentrations ranging from 0.5 to 100 M for 96 h, the incubation medium was replaced with 100 M 4-trifluoromethyl-7-hydroxycoumarin and 100 M -estradiol, which are probe substrates of UGT1A9/2B7 and UGT1A1/1A3, respectively, for an additional incubation of 30 min

Alpha lipoic acid, L-glutamine, vitamin C and vitamin E play a supporting role in the regeneration of glutathione via recycling actions, with vitamin C converting oxidised glutathione into its reduced form, and vitamin E having the same effect on vitamin C by recycling dehydroascorbic acid (oxidised ascorbic acid) back to ascorbic acid

doi: 10.1111/j.1365-2133.2008.08759.x