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For example, PPIs are linked to nutrient deficiencies, 11 bone demineralization, 12 and higher susceptibility to infections, including Clostridium difficile
It inhibits the activation of the transcription factor NF-B, reducing the production of pro-inflammatory cytokines (IL-1, TNF-, IL-6) and inflammatory mediators (PGE2, NO)
While this might sound like an advantage, it requires careful monitoring
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