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Over 72 weeks, participants without type 2 diabetes achieved the following weight loss results : 5 mg dose: 16.0% average body weight reduction 10 mg dose: 21.4% average body weight reduction 15 mg dose: 22.5% average body weight reduction Placebo: 2.4% average body weight reduction At the highest dose, 92.7% of participants achieved at least 5% weight loss, 84.4% achieved at least 10%, 73.6% achieved at least 15%, 56.1% achieved at least 20%, and 38.7% achieved at least 25% weight loss

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Sidaks post-hoc test p values corrected for multiple comparisons: B6 vs B6/Rab4A Q72L -KO p = 0.0193, B6 vs B6.TC p = 0.0006, B6/Rab4A Q72L vs B6.TC/Rab4A Q72L p = 0.0001, B6,TC vs B6.TC/Rab4A Q72L p = 0.0398