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In the LEADER trial, over 9,340 patients with type 2 diabetes and high cardiovascular disease risk underwent randomization to liraglutide or placebo and were followed for a median of 3.8 years resulting in a 13% risk reduction in a combined endpoint of death from cardiovascular cause, nonfatal myocardial infarction, or nonfatal stroke [46]

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Initial results from studies in rodents suggested a synergistic role of dual GLP-1 and glucagon agonism on reducing food intake and led to the development of numerous unimolecular GLP-1/glucagon co-agonists