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Notably, the concentration of e-CAT in humans was higher than in other mammalian species, exceeding five to six times the levels in goat and sheep

That said, many people respond incredibly well to conservative rehab, even without surgery

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The pipeline continues to expand: Novo Nordisk filed an NDA for CagriSema (semaglutide + cagrilintide) in December 2025, which achieved 22.7% weight loss in the REDEFINE 1 trial, and Eli Lilly reported Phase 3 results for retatrutide , a triple GIP/GLP-1/glucagon agonist that delivered 28.7% weight loss