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Cystine is readily imported into cells where it is converted to cysteine, the limiting precursor for GSH formation ( FIGURE 3 Induction of Changes in Intracellular ROS and Function in Response to Physiological Variations in Extracellular Redox Couples A redox communication system that shares information among metabolically sensitive tissues predicts that physiologically relevant changes in the putative redox indicator ratios will impact tissue ROS production and function
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