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Mean body weight reduction with liraglutide titrated up to 3.0 mg ranged from 2.3 to 12.3 kg, while patients on semaglutide up to 2.4 mg experienced a mean body weight reduction ranging from 8.2 to 15.8 kg

In addition, the benchmarking approach provides an alternative to the traditional validation of NAMS against apical effects in rodent studies but rather tries to evaluate the NAMs in the context of making protective safety decisions (Browne et al., 2024)