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Given the high prevalence of psychiatric comorbidities, undertaking randomized controlled trials in patients with primary polydipsia is difficult and is also mirrored by the lack of research in this field (5)

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361 Jayaraman et al

Preclinical (animal) data Rodent studies suggest BPC-157 may: Promote blood vessel growth Enhance tendon fibroblast activity Reduce inflammation Protect gastrointestinal tissues However, these findings: Use doses far above any human equivalent Use controlled laboratory injuries Do not predict human efficacy 2