The contribution of oxidation in PD pathogenesis has also been supported through clinical studies reporting alterations in serum glutathione peroxidase and superoxide dismutase activities, together with high malondialdehyde (MDA) levels in PD patients 23,24
- This study investigated the association of semaglutide 2.4 mg with major adverse cardiovascular events among individuals with overweight/obesity without diabetes who had risk factors for atherosclerotic cardiovascular disease.- This study investigated the association of semaglutide 2.4 mg with major adverse cardiovascular events among individuals with overweight/obesity without diabetes who had risk factors for atherosclerotic cardiovascular disease.- 48,184 patients initiating semaglutide 2.4 mg were propensity-score matched 1:2 to those not on semaglutide 2.4 mg (96,368 individuals).- In this study, semaglutide 2.4 mg was associated with a lower risk of incident major adverse cardiovascular events and heart failure composite outcomes.- Exploratory analyses further demonstrated consistent lower risks of obesity-related outcomes, including incident type 2 diabates, major adverse kidney events, acute kidney injury, major obesity-related adverse events, and all-cause hospitalization.Association between semaglutide 2.4 mg and risk of cardiovascular events in people with overweight or obesity without atherosclerotic cardiovascular disease in the real-world: The SCORE primary prevention study (open access) doi.org/10.1016/j.ajpc
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